GITR Ligand Monoclonal / PE / REA841

Citations: (1)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-112-973 (View supplier product page)
Size 100 tests in 200 µL
Price $315.00
Antigen GITR Ligand
Clone REA841
Host Human
Isotype IgG1
Conjugate PE
Target Species Human
Applications FC
Description Clone REA841 recognizes the human GITRL, also known as the ligand for GITR (glucocorticoid-induced TNF receptor superfamily-related protein) and also called AITR (activation-inducible TNF receptor superfamily-related protein). GITRL, a type II membrane protein and a member of the TNF superfamily, is highly expressed in small intestine, ovary, testis, kidney, and endothelial cells. GITRL is not found in resting or stimulated T cells, B cells, or peripheral blood mononuclear cells (PBMCs). After stimulation by bacterial lipopolysaccharides (LPS), GITRL is upregulated. GITR and GITRL might play an important role for interactions between activated T lymphocytes and endothelial cells. Furthermore, overexpression on monocyte-derived DC enhances their capacity to induce antigen-specific T cell responses. | Additional information: Clone REA841 displays negligible binding to Fc receptors.
Citations
PMID 10037686
PMID 10074428
PMID 16868552
PMID 17449724
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PE Excitation and Emission Spectra