CD357 Monoclonal / Biotin / REA1007

Citations: (3)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-116-844 (View supplier product page)
Size 100 tests in 200 µL
Price $270.00
Antigen CD357
Clone REA1007
Host Human
Isotype IgG1
Conjugate Biotin
Target Species Human
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Description Clone REA1007 recognizes the human CD357 antigen, also known as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) or TNFRSF18, which is an inducible type I transmembrane protein and a member of the tumor necrosis factor receptor (TNFR) superfamily. CD357 is expressed at low levels on thymocyte subsets, resting T cells, B cells, and macrophages, and at high levels on CD4+CD25+ regulatory T cells (Tregs). Upon activation, expression on CD4+ and CD8+ T cells is upregulated. Triggering of GITR has been described to modulate Treg function and co-stimulate effector T cells. Stimulation of T cells through GITR can abrogate the inhibitory function of Tregs. It is hypothesized that GITR has a role in the maintenance of immunological self tolerance, and mouse models of autoimmune disease suggest that GITR activation may break self-tolerance and induce autoimmunity. | Additional information: Clone REA1007 displays negligible binding to Fc receptors.
About CD357 and Biotin
CD357 This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Citations
Reviews & Ratings
Biotin Excitation and Emission Spectra