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	Supplier	Miltenyi Biotec
	Catalog #:	130-116-424 (View supplier product page)
	Size	30 µg in 200 µL
	Price	$65.00
	Antigen	CD357
	Clone	REA980
	Host	Human
	Isotype	IgG1
	Conjugate	Biotin
	Target Species	Mouse
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
	Description	Clone REA980 recognizes the mouse CD357 antigen, also known as glucocorticoid-induced TNF-receptor (GITR) or TNFRSF18. CD357 is a member of the TNF receptor superfamily. It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ regulatory T cells (Tregs). Activation of T cells upregulates CD357 expression. Interaction of CD357 (GTITR) with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. CD357 plays an important role in the function of CD4+CD25+ Tregs. \| Additional information: Clone REA980 displays negligible binding to Fc receptors.

	CD357	This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

$65.00
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CD357 Monoclonal / Biotin / REA980