CD2 Monoclonal / PE / REA972
CD2 Monoclonal / PE / REA972
Citations:
(2)
Product Details
Supplier | Miltenyi Biotec | |
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Catalog #: | 130-116-252 (View supplier product page) | |
Size | 30 tests in 60 µL | |
Price | $120.00 | |
Antigen | CD2 | |
Clone | REA972 | |
Host | Human | |
Isotype | IgG1 | |
Conjugate | PE | |
Target Species | Human | |
Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC, Mass Cytometry | |
Description | Clone REA972 recognizes the human CD2 antigen, a 50 kDa single-chain transmembrane glycoprotein also known as LFA-2 or receptor for sheep erythrocytes. CD2 functions as a costimulatory molecule on T and natural killer (NK) cells and is a receptor for other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58). It belongs to the Ig superfamily and is involved in cell signaling and lymphocyte adhesion. The CD2 antibody reacts with 80–90% of peripheral blood lymphocytes and more than 95% of thymocytes and recognizes all T cells and a subset of NK cells. | Additional information: Clone REA972 displays negligible binding to Fc receptors. |
About CD2 and PE
CD2 | The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016] | |
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PE | Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts. |
Citations
PMID 6984191 | ||
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PMID 9379483 | ||
Additional Sources |
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Reviews & Ratings
PE Excitation and Emission Spectra
$120.00
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