CD158b (KIR2DL2/DL3) Monoclonal / PE / REA1006
CD158b (KIR2DL2/DL3) Monoclonal / PE / REA1006
Citations:
(4)
Product Details
| Supplier | Miltenyi Biotec | |
|---|---|---|
| Catalog #: | 130-116-952 (View supplier product page) | |
| Size | 30 tests in 60 µL | |
| Price | $130.00 | |
| Antigen | CD158b (KIR2DL2/DL3) | |
| Clone | REA1006 | |
| Host | Human | |
| Isotype | IgG1 | |
| Conjugate | PE | |
| Target Species | Human | |
| Applications | FC, Mass Cytometry | |
| Description | Clone REA1006 recognizes the human CD158b1 (KIR2DL2), CD158b2 (KIR2DL3), and CD158j (KIR2DS2) antigens, members of the killer immunoglobulin-like receptor (KIR) family expressed on natural killer (NK) cells and subsets of T cells. | KIRs contribute to the regulation of NK cell–mediated cytotoxicity and possess high allelic polymorphism with either 2 or 3 Ig-like extracellular domains. According to the length of their cytoplasmic tail, KIRs can be further subdivided in inhibitory KIRs (KIR2DL or KIR3DL) and activating KIRs (KIR2DS or KIR3DS). CD158b provides an inhibitory signal on NK cell lytic activity upon interaction with HLA C (e.g. alleles HLA-Cw1, HLA-Cw3, HLA-Cw7) in an antigen-independent manner. | Additional information: Clone REA1006 displays negligible binding to Fc receptors. |
Citations
| PMID 9059894 | ||
|---|---|---|
| PMID 11895890 | ||
| PMID 12200350 | ||
| PMID 12493005 | ||
| Additional Sources |
|
Reviews & Ratings
PE Excitation and Emission Spectra
$130.00
Supplier Page
Supplier Page
