FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-113-231 (View supplier product page)
	Size	100 tests in 200 µL
	Price	$335.00
	Antigen	CD11b
	Clone	M1/70.15.11.5
	Host	Rat
	Isotype	IgG2b κ
	Conjugate	APC
	Target Species	Human, Mouse
	Applications	MICS (MACSima Imaging Cyclic Staining), FC, IF, IHC
	Description	CD11b, also known as Mac-1 α or integrin αM chain, is part of the CD11b/CD18 heterodimer (Mac-1 α, Mβ2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on NK cells and some activated lymphocytes as well as on microglia in the brain. In mice, the CD11b antigen is expressed on monocytes/macrophages and microglia. To a lower extent it is expressed on granulocytes, NK cells, CD5+ B-1 cells, and subsets of dendritic cells. The monoclonal M1/70.15.11.5 antibody recognizes the human, mouse, and non-human primate CD11b antigen.

	CD11b	This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

$335.00
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CD11b Monoclonal / APC / M1/70.15.11.5