FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-116-440 (View supplier product page)
	Size	30 tests in 60 µL
	Price	$130.00
	Antigen	AN2
	Clone	REA989
	Host	Human
	Isotype	IgG1
	Conjugate	PE
	Target Species	Human, Mouse
	Applications	MICS (MACSima Imaging Cyclic Staining), IF, IHC, FC
	Description	Clone REA989 recognizes the human and mouse AN2 antigen. AN2 is the mouse homolog of the rat NG2 and human Melanoma (MCSP) proteins. NG2 is a chondroitin sulfate glycoprotein that is expressed by glial progenitor cells in the developing and adult central nervous system (CNS) and by immature Schwann cells. NG2/AN2+ glia has been identified as a fourth major glial cell type in the mammalian CNS that is distinct from other cell types. NG2/AN2+ cells are precursors of oligodendrocytes and some protoplasmic astrocytes in the gray matter. NG2/AN2 expression is down-regulated before the cells undergo terminal differentiation. However, a population of NG2/AN2+ cells remains in the white and gray matter after oligodendrocytes are generated. NG2/AN2+ glial cells participate in neuron-glial circuits by receiving presynaptic input from neurons and responding to neurotransmitters released by synapses. Many highly migratory neural tumors including melanomas express NG2/AN2. \| Additional information: Clone REA989 displays negligible binding to Fc receptors.

	AN2	A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]
	PE	Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.

$130.00
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AN2 Monoclonal / PE / REA989