NALCN Monoclonal / Streptavidin / S187-7

Product Details
Supplier Stressmarq
Catalog #: SMC-417D-STR (View supplier product page)
Size 100 μg
Price $339.00
Antigen NALCN
Clone S187-7
Host Mouse
Isotype IgG1
Conjugate Streptavidin
Target Species Human, Mouse, Rat
Applications WB, ICC/IF
Description Mouse Anti-Rat NALCN Monoclonal IgG1
About NALCN and Streptavidin
NALCN This gene encodes a voltage-independent, nonselective cation channel which belongs to a family of voltage-gated sodium and calcium channels that regulates the resting membrane potential and excitability of neurons. This family is expressed throughout the nervous system and conducts a persistent sodium leak current that contributes to tonic neuronal excitability. The encoded protein forms a channelosome complex that includes G-protein-coupled receptors, UNC-79, UNC-80, NCA localization factor-1, and src family tyrosine kinases. Naturally occurring mutations in this gene are associated with infantile neuroaxonal dystrophy, infantile hypotonia with psychomotor retardation and characteristic facies (IHPRF) syndrome, and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD) syndrome. A knockout of the orthologous gene in mice results in paralysis with a severely disrupted respiratory rhythm, and lethality within 24 hours after birth. [provided by RefSeq, Apr 2017]
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Streptavidin Excitation and Emission Spectra