Axin-2 Polyclonal / Streptavidin /

Product Details
Supplier Stressmarq
Catalog #: SPC-750D-STR (View supplier product page)
Size 100 μg
Price $339.00
Antigen Axin-2
Clone
Host Rabbit
Isotype IgG
Conjugate Streptavidin
Target Species Human, Rat
Applications WB, IHC
Description Rabbit Anti-Human Axin-2 Polyclonal
About Axin-2 and Streptavidin
Axin-2 The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
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Streptavidin Excitation and Emission Spectra