Cyclin D3 Polyclonal / ATTO 633 /

Product Details
Supplier Stressmarq
Catalog #: SPC-732D-A633 (View supplier product page)
Size 100 μg
Price $341.00
Antigen Cyclin D3
Clone
Host Rabbit
Isotype IgG
Conjugate ATTO 633
Target Species Human, Mouse, Rat
Applications WB, IHC
Description Rabbit Anti-Human Cyclin D3 Polyclonal
About Cyclin D3 and ATTO 633
Cyclin D3 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
ATTO 633 ATTO 633 from ATTO-TEC has an excitation peak at 629 nm and an emission peak at 657 nm. ATTO 633 belongs to a new generation of fluorescent labels for the red spectral region. Characteristic features of the label are strong absorption, high fluorescence quantum yield, and high thermal and photo-stability. Thus ATTO 633 is highly suitable for single-molecule detection applications and high-resolution microscopy such as SIM, STED etc. Additionally the dye highly qualifies to be applied in flow cytometry (FACS), fluorescence in-situ hybridization (FISH) and many more. In common with most ATTO-labels, absorption and fluorescence are independent of pH, at least in the range of pH 2 to 11, used in typical applications. ATTO 633 is a cationic dye. After coupling to a substrate the label carries a net electrical charge of +1. The label is moderately hydrophilic.
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ATTO 633 Excitation and Emission Spectra