ErbB2 Polyclonal / ATTO 565 /

Product Details
Supplier Stressmarq
Catalog #: SPC-1136D-A565 (View supplier product page)
Size 100 μl
Price $342.00
Antigen ErbB2
Clone
Host Rabbit
Isotype IgG
Conjugate ATTO 565
Target Species Human, Mouse
Applications WB, Microarray
Description Rabbit Anti-Human ErbB2 Polyclonal
About ErbB2 and ATTO 565
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
ATTO 565 ATTO 565 from ATTO-Tec Gmbh has an excitation peak at 563 nm and an emission peak at 592 nm.
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ATTO 565 Excitation and Emission Spectra