ErbB3 Polyclonal / ATTO 594 /

Product Details
Supplier Stressmarq
Catalog #: SPC-1138D-A594 (View supplier product page)
Size 100 μl
Price $384.00
Antigen ErbB3
Clone
Host Rabbit
Isotype IgG
Conjugate ATTO 594
Target Species Human, Mouse
Applications WB, Microarray
Description Rabbit Anti-Human ErbB3 Polyclonal
About ErbB3 and ATTO 594
ErbB3 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
ATTO 594 ATTO 594 from ATTO-TEC has an excitation peak at 601 nm and an emission peak at 627 nm. ATTO 594 is a novel fluorescent label belonging to the class of rhodamine dyes. Characteristic features of the label are strong absorption, high fluorescence quantum yield, high thermal and photo-stability, and excellent water solubility. Thus ATTO 594 is highly suitable for single-molecule detection applications and high-resolution microscopy such as PALM, dSTORM, STED etc. Additionally the dye highly qualifies to be applied in flow cytometry (FACS), fluorescence in-situ hybridization (FISH) and many more. ATTO 594 is very hydrophilic and shows a very good water solubility. After coupling to a substrate the label carries a net electrical charge of -1.
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ATTO 594 Excitation and Emission Spectra