Presenilin-1 Polyclonal / ATTO 488 /

Product Details
Supplier Stressmarq
Catalog #: SPC-734D-A488 (View supplier product page)
Size 100 μg
Price $383.00
Antigen Presenilin-1
Clone
Host Rabbit
Isotype IgG
Conjugate ATTO 488
Target Species Human, Mouse, Rat
Applications WB, IHC
Description Rabbit Anti-Human Presenilin 1 Polyclonal
About Presenilin-1 and ATTO 488
Presenilin-1 Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
ATTO 488 ATTO 488 is from ATTO-Tec Gmbh has an excitation peak at 501 nm and an emission peak at 523 nm.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

ATTO 488 Excitation and Emission Spectra