GRP78 Monoclonal / ATTO 488 / 6H4-2G7

Product Details
Supplier Stressmarq
Catalog #: SMC-196D-A488 (View supplier product page)
Size 100 μg
Price $355.00
Antigen GRP78
Clone 6H4-2G7
Host Mouse
Isotype IgG1
Conjugate ATTO 488
Target Species Bovine, Fungi, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Xenopus
Applications ICC/IF, IHC
Description Mouse Anti-Human GRP78 Monoclonal IgG1
About GRP78 and ATTO 488
GRP78 The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]
ATTO 488 ATTO 488 is from ATTO-Tec Gmbh has an excitation peak at 501 nm and an emission peak at 523 nm.
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ATTO 488 Excitation and Emission Spectra