Wilm's Tumor 1 Monoclonal / CF568 / WT1/857 6F-H2

Product Details
Supplier Biotium
Catalog #: BNC681138-500 (View supplier product page)
Size 500 μl
Price $551.00
Antigen Wilm's Tumor 1
Clone WT1/857 6F-H2
Host Mouse
Isotype IgG
Conjugate CF568
Target Species Human, Mouse, Rat
Applications IHC, IHC FFPE
Description WT1 (Wilm's Tumor 1)(WT1/857 + 6F-H2), CF568 conjugate, 0.1mg/mL
About Wilm's Tumor 1 and CF568
Wilm's Tumor 1 This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
CF568 CF®568 from Biotium is a fluorophore with an excitation peak at 562 nm and an emission peak at 583 nm. It can be useful in both fluorescence microscopy and flow cytometry. It is spectrally similar to Alexa Fluor™ 568 and ATTO 565. However, in flow cytometry, a superior alternative is R-PE. In microscopy, CF®568 is validated in super-resolution imaging by STORM, STED, Structured Illumination (SIM) and TIRF.
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CF568 Excitation and Emission Spectra