Wilm's Tumor 1 Monoclonal / CF680 / rWT1/857

Product Details
Supplier Biotium
Catalog #: BNC801856-500 (View supplier product page)
Size 500 μl
Price $470.00
Antigen Wilm's Tumor 1
Clone rWT1/857
Host Mouse
Isotype IgG1 κ
Conjugate CF680
Target Species Human
Applications IHC FF, IF, FC
Description Wilm's Tumor 1 / WT1 Recombinant Monoclonal Mouse Antibody (rWT1/857)
About Wilm's Tumor 1 and CF680
Wilm's Tumor 1 This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
CF680 CF®680 from Biotium is a fluorophore with an excitation peak at 681 nm and an emission peak at 698 nm. It can be useful in both fluorescence microscopy and flow cytometry. It is spectrally similar to Alexa Fluor™ 680, IRDye® 680 and Cy5.5.
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CF680 Excitation and Emission Spectra