CD45 Monoclonal / CF543 / 136-4B5

Product Details
Supplier Biotium
Catalog #: BNC430173-500 (View supplier product page)
Size 500 μl
Price $470.00
Antigen CD45
Clone 136-4B5
Host Mouse
Isotype IgG1 κ
Conjugate CF543
Target Species Human
Applications IF, IHC-P, FC
Description CD45 / LCA Monoclonal Mouse Antibody (136-4B5)
About CD45 and CF543
CD45 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
CF543 CF®543 from Biotium is a fluorophore with an excitation peak at 541 nm and an emission peak at 560 nm. It can be useful in both fluorescence microscopy and flow cytometry.
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CF543 Excitation and Emission Spectra