MAGE-A1 KVLEYVIKV (Dextramer) Monoclonal / Unconjugated / MA454

Product Details
Supplier Biotium
Catalog #: BNUM0008-50 (View supplier product page)
Size 50 μl
Price $410.00
Antigen MAGE-A1 KVLEYVIKV (Dextramer)
Clone MA454
Host Mouse
Isotype IgG1 κ
Conjugate Unconjugated
Target Species Canine, Human, Rat
Applications FC, ICS, ELISA, IHC, IHC-P, WB
Description Recognizes a protein of 42-46 kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8 T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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Purified Excitation and Emission Spectra