CD40 / SuperBright 436 / 1C10
CD40 / SuperBright 436 / 1C10
Product Details
| Supplier | Thermo Fisher Scientific | |
|---|---|---|
| Catalog #: | 62-0401-80 (View supplier product page) | |
| Size | 25 μg | |
| Price | $149.00 | |
| Antigen | CD40 | |
| Clone | 1C10 | |
| Host | Rat | |
| Isotype | IgG2a κ | |
| Conjugate | SuperBright 436 | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | CD40 Monoclonal Antibody (1C10), Super Bright 436, eBioscience |
About CD40 and SuperBright 436
| CD40 | This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] | |
|---|---|---|
| SuperBright 436 | SuperBright 436 (SB436) is a fluorescent polymer with an excitation peak at 414 nm and an emission peak at 436 nm. SB436 is spectrally similar to StarBright Violet 440, eFluor™ 450 and Pacific Blue but can be unmixed with Brilliant™ Violet 421 on a spectral analyzer. This dye is a member of the SuperBright dye family, sold by ThermoFisher Scientific under license from BD Bioscience. |
Images
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Staining of BALB/c splenocytes with Anti-Mouse CD19 FITC (Product # 11-0193) and 0.25 µg of Rat IgG2a K Isotype Control Super Bright 436 (Product # 62-4321) (left) or 0.25 µg of Anti-Mouse CD40 Super Bright 436 (Product # 62-0401) (right). Total viable cells were used for analysis. |
Citations
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Reviews & Ratings
SuperBright 436 Excitation and Emission Spectra
$149.00
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