DUSP3 / Unconjugated /

Citations: (6)
Product Details
Supplier Cell Signaling Technology
Catalog #: 4752S (View supplier product page)
Size 100 μl
Price $306.00
Antigen DUSP3
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Monkey, Mouse, Rat
Applications WB, IP
Description DUSP3/VHR Antibody detects endogenous levels of total DUSP3 protein. This antibody does not cross-react with other dual-specific phosphatases.
About DUSP3 and Purified
DUSP3 The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra