Vav-1 / Unconjugated / D45G3

Citations: (8)
Product Details
Supplier Cell Signaling Technology
Catalog #: 4657T (View supplier product page)
Size 20 μl
Price $145.00
Antigen Vav-1
Clone D45G3
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications WB, IP
Description Vav1 (D45G3) Rabbit mAb recognizes endogenous levels of total Vav1 protein.
About Vav-1 and Purified
Vav-1 This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
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Purified Excitation and Emission Spectra