Glutamate Dehydrogenase / Unconjugated / D9F7P

Citations: (34)
Product Details
Supplier Cell Signaling Technology
Catalog #: 12793S (View supplier product page)
Size 100 μl
Price $339.00
Antigen Glutamate Dehydrogenase
Clone D9F7P
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Monkey, Mouse, Rat
Applications WB, IHC-P, IF
Description Glutamate Dehydrogenase 1/2 (D9F7P) Rabbit mAb recognizes endogenous levels of total glutamate dehydrogenase 1 and 2 proteins. Species cross-reactivity for IHC-P and IF-IC is in human only.
About Glutamate Dehydrogenase and Purified
Glutamate Dehydrogenase This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016]
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Purified Excitation and Emission Spectra