Glucocorticoid Receptor / Unconjugated / D8H2

Product Details
Supplier Cell Signaling Technology
Catalog #: 3660T (View supplier product page)
Size 20 μl
Price $155.00
Antigen Glucocorticoid Receptor
Clone D8H2
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Monkey, Mouse, Rat
Applications WB, IF, FC, ChIP, IP, ChIP-seq
Description Glucocorticoid Receptor (D8H2) XP Rabbit mAb recognizes endogenous levels of total glucocorticoid receptor protein. Based upon sequence alignment, this antibody is predicted to cross-react with all known alternative translation start site generated isoforms of glucocorticoid receptor-alpha and glucocorticoid receptor-beta. This antibody does not cross-react with mineralocorticoid receptor.
About Glucocorticoid Receptor and Purified
Glucocorticoid Receptor This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
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Purified Excitation and Emission Spectra