53BP1 / Unconjugated /

Citations: (245)
Product Details
Supplier Cell Signaling Technology
Catalog #: 4937S (View supplier product page)
Size 100 μl
Price $306.00
Antigen 53BP1
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Monkey
Applications WB, IHC-P, IF
Description 53BP1 Antibody detects endogenous levels of total 53BP1 protein independent of phosphorylation.
About 53BP1 and Purified
53BP1 This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
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Purified Excitation and Emission Spectra