PD-1 / Brilliant Violet 605 / NAT105
PD-1 / Brilliant Violet 605 / NAT105
Citations:
(2)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 367425 (View supplier product page) | |
| Size | 25T | |
| Price | $209.00 | |
| Antigen | PD-1 | |
| Clone | NAT105 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | Brilliant Violet 605 | |
| Target Species | Human | |
| Applications | FC | |
| Description | Brilliant Violet 605 anti-human CD279 (PD-1) |
About PD-1 and Brilliant Violet 605
| PD-1 | Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020] | |
|---|---|---|
| Brilliant Violet 605 | Brilliant™ Violet 605 (BV605) is an orange/red-emitting tandem fluorophore that can be excited by the 405 nm Violet laser and collected using a 610/20 bandpass filter. BV605 has an excitation peak at 405 nm and an and emission peak at 603 nm. BV605 is most commonly used in flow cytometry and is spectrally similar to SuperBright 600 (Thermo Fisher), SuperNova v605 (Beckman Coulter) and StarBright Violet 610 (Bio-Rad). BV605 is considered to be relatively bright and should be used on antigens of moderate to low abudance. This dye is part of the Brilliant™ Violet dye line of fluorescent polymers. Brilliant™ Violet 421 polymer is employed as the donor molecule in a series of tandem dyes with acceptor molecules emitting at various points across the visible light spectrum. The Brilliant™ Violet dyes are a superior alternative to QDot nanocrystals and similar to SuperNova dye from Beckman Coulter and StarBright dyes from Bio-Rad. |
Images
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Human peripheral blood lymphocytes were stained with CD3 FITC and CD279 (clone NAT105) Brilliant Violet 605™ (top), or mouse IgG1, κ Brilliant Violet 605™ isotype control (bottom). |
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PHA-stimulated (3-day) human peripheral blood lymphocytes were stained with CD279 (clone NAT105) Brilliant Violet 605™ (filled histogram) or mouse IgG1, κ Brilliant Violet 605™ isotype control (open histogram). |
Citations
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Reviews & Ratings
Brilliant Violet 605 Excitation and Emission Spectra
$209.00
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