MSR1 / Brilliant Blue 700 / U23-56

Product Details
Supplier BD Biosciences
Catalog #: 745801 (View supplier product page)
Size 50 μg
Price $538.00
Antigen MSR1
Clone U23-56
Host Mouse
Isotype IgG1 κ
Conjugate Brilliant Blue 700
Target Species Human
Applications FC
Description Hu MSR1 (CD204) BB700 U23-56 50ug
About MSR1 and Brilliant Blue 700
MSR1 This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Brilliant Blue 700 Horizon Brilliant™ Blue 700 (BB700) from BD Biosciences is a tandem dye of BB515. It has an excitation peak at 484 nm and an emission peak at 695 nm, making it spectrally comparable to PerCP-Cy5.5.
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Brilliant Blue 700 Excitation and Emission Spectra