IL-21 R / Brilliant Violet 711 / 17A12
IL-21 R / Brilliant Violet 711 / 17A12
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 359511 (View supplier product page) | |
| Size | 25T | |
| Price | $193.00 | |
| Antigen | IL-21 R | |
| Clone | 17A12 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | Brilliant Violet 711 | |
| Target Species | Human | |
| Applications | FC | |
| Description | Brilliant Violet 711 anti-human CD360 (IL-21R) |
About IL-21 R and Brilliant Violet 711
| IL-21 R | The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] | |
|---|---|---|
| Brilliant Violet 711 | Brilliant™ Violet 711 (BV711) is a red-emitting tandem fluorophore that can be excited by the 405 nm Violet laser and collected using a 710/50 bandpass filter. BV711 has an excitation peak at 405 nm and an emission peak at 711 nm. BV711 exhibits a medium level of brightness and is most often used in flow cytometry, specifically, it is an alternative to nanocrystals used for intracellular flow. This dye is part of the Brilliant™ Violet dye line of fluorescent polymers. Brilliant™ Violet 421 polymer is employed as the donor molecule in a series of tandem dyes with acceptor molecules emitting at various points across the visible light spectrum. The Brilliant™ Violet dyes are a superior alternative to QDot nanocrystals and similar to SuperNova dye from Beckman Coulter and StarBright dyes from Bio-Rad. |
Images
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Human peripheral blood lymphocytes were stained with CD19 PE and CD360 (IL-21R) Brilliant Violet 711™ (clone 17A12) (top) or mouse IgG1, κ PE isotype control (bottom) |
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Citations
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Reviews & Ratings
Brilliant Violet 711 Excitation and Emission Spectra
$193.00
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