CD14 Monoclonal / PE / REA934
CD14 Monoclonal / PE / REA934
Citations:
(3)
Product Details
Supplier | Miltenyi Biotec | |
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Catalog #: | 130-115-440 (View supplier product page) | |
Size | 150 µg in 1 mL | |
Price | $240.00 | |
Antigen | CD14 | |
Clone | REA934 | |
Host | Human | |
Isotype | IgG1 | |
Conjugate | PE | |
Target Species | Mouse | |
Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC | |
Description | Clone REA934 recognizes the mouse CD14 antigen, a cell surface glycoprotein preferentially expressed on monocytes/macrophages, but also on granulocytes, dendritic cells, Kupffer cells, and hepatocytes. In association with toll-like receptors TLR 4 and MD-2, CD14 is a highly specific co-receptor for bacterial lipopolysaccharide (LPS) and for a variety of other pathogen-associated molecular patterns of microbial sources. The association of CD14 with LPS is mediated by the LPS-binding protein (LBP). | Additional information: Clone REA934 displays negligible binding to Fc receptors. |
About CD14 and PE
CD14 | The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020] | |
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PE | Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts. |
Citations
PMID 1694207 | ||
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PMID 16148141 | ||
PMID 19362712 | ||
Additional Sources |
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Reviews & Ratings
PE Excitation and Emission Spectra
$240.00
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