Endostatin / DyLight 680 / RM0060-3H11

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-12274FR (View supplier product page)
Size 0.1 ml
Price $549.00
Antigen Endostatin
Clone RM0060-3H11
Host Rat
Isotype IgG2
Conjugate DyLight 680
Target Species Mouse
Applications WB, IHC-P, IHC
Description Rat Endostatin antibody reacts with Mouse [DyLight 680]
About Endostatin and DyLight 680
Endostatin This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
DyLight 680 DyLight™ 680 has an excitation peak at 692 nm and an emission peak at 712 nm, and is spectrally similar to Alexa Fluor™ 680 and Cy5.5. DyLight™ 680 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 680 Excitation and Emission Spectra