CD45 / PE-Dazzle 594 / HI30
CD45 / PE-Dazzle 594 / HI30
Citations:
(1)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 982308 (View supplier product page) | |
| Size | 500UL | |
| Price | $467.00 | |
| Antigen | CD45 | |
| Clone | HI30 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | PE-Dazzle 594 | |
| Target Species | Human | |
| Applications | FC | |
| Description | PE/Dazzle 594 anti-human CD45 |
About CD45 and PE-Dazzle 594
| CD45 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012] | |
|---|---|---|
| PE-Dazzle 594 | PE-Dazzle® 594 (RPE-Dazzle 594) from Biolegend is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Dazzle 594. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Dazzle 594, which emitts light that can be captured with a 610/20 nm bandpass filter. PE-Dazzle 594 has an excitation peak at 565 nm and an emission peak at 610 nm, and is suitable alternative to PE-Texas Red, PE-eF610, PE-Alexa Fluor™ 610 or PE-CF®594. |
Images
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Typical results from human peripheral bloodlymphocytes stained either with HI30PE/Dazzle™ 594 used at 5 µL/test (filledhistogram) or with an isotype control (openhistogram). |
Citations
| PMID 18544681 | ||
|---|---|---|
| PMID 21138865 | ||
| PMID 22828869 | ||
| PMID 24648400 | ||
| PMID 25672754 | ||
| PMID 25687281 | ||
| PMID 25687283 | ||
| Additional Sources |
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Reviews & Ratings
PE-Dazzle 594 Excitation and Emission Spectra
$467.00
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