FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-114-311 (View supplier product page)
	Size	100 tests in 200 µL
	Price	$320.00
	Antigen	IKZF3
	Clone	REA881
	Host	Human
	Isotype	IgG1
	Conjugate	APC
	Target Species	Human
	Applications	FC
	Description	Clone REA881 recognizes the human transcription factor aiolos, also known as IKZF3. Aiolos is a member of the ikaros family of zinc-finger proteins and forms heterodimers with other ikaros family members. It plays an essential role in the control of B lymphocyte differentiation and proliferation and in the regulation of BCL2 expression. Furthermore, it is involved in controlling apoptosis in T cells in an IL-2–dependent manner. Aiolos is found in peripheral blood leukocytes, spleen, and thymus. \| Additional information: Clone REA881 displays negligible binding to Fc receptors.

	IKZF3	This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

$320.00
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IKZF3 Monoclonal / APC / REA881