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	Supplier	Miltenyi Biotec
	Catalog #:	130-115-320 (View supplier product page)
	Size	30 tests in 60 µL
	Price	$150.00
	Antigen	EZH2
	Clone	REA907
	Host	Human
	Isotype	IgG1
	Conjugate	Vio 515
	Target Species	Human, Mouse
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
	Description	Clone REA907 recognizes the human and mouse EZH2 protein, a methyltransferase which plays an essential role in the regulation of homeobox gene expression. EZH2, also known as enhancer of zeste homolog 2, belongs to the polycomp group (PcG). Members of this family play an essential role in stem-cell identity as well as cellular differentiation during development via transcriptional repression and disease. EZH2, first described in drosophila, is found in higher levels in different kind of tumor cells, and it is also expressed in thymocytes, and, depending on their stage, subsets of T cells and B cells. \| Additional information: Clone REA907 displays negligible binding to Fc receptors.

	EZH2	This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
	Vio 515	Vio® 515 from Miltenyi has an excitation peak at 488 nm and an emission peak at 514. It is spectrally comparable to FITC, Alexa Fluor™ 488, CF®488A and DyLight™ 488.

$150.00
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EZH2 Monoclonal / Vio 515 / REA907