FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-115-231 (View supplier product page)
	Size	100 tests in 200 µL
	Price	$365.00
	Antigen	ABCG2
	Clone	REA909
	Host	Human
	Isotype	IgG1
	Conjugate	PE-Vio770
	Target Species	Human
	Applications	FC
	Description	Clone REA909 recognizes the human CD338 antigen, a multi-pass membrane protein which is also known as ATP-binding cassette sub-family G member 2 (ABCG2) or breast cancer resistance protein (BCRP). CD338 is a member of the ATP-binding cassette (ABC) transporter superfamily and known to contribute to multidrug resistance in cancer chemotherapy. It is highly expressed on primitive stem cells as identified by the side-population phenotype, which is characterized by the efflux of chemicals, including the fluorescent dye Hoechst 33342 and Rhodamine 123. Among ABC transporters that are known to cause multidrug resistance, CD338 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure. \| Additional information: Clone REA909 displays negligible binding to Fc receptors.

	ABCG2	The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
	PE-Vio770	PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.

$365.00
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ABCG2 Monoclonal / PE-Vio770 / REA909