ErbB3 / Biotin / D22C5

Product Details
Supplier Cell Signaling Technology
Catalog #: 14800S (View supplier product page)
Size 100 μl
Price $450.00
Antigen ErbB3
Clone D22C5
Host Rabbit
Isotype IgG
Conjugate Biotin
Target Species Human, Mouse
Applications WB
Description HER3/ErbB3 (D22C5) XP Rabbit mAb (Biotinylated) recognizes endogenous levels of total HER3/ErbB3 protein. This antibody does not cross-react with other HER family proteins.
About ErbB3 and Biotin
ErbB3 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
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Biotin Excitation and Emission Spectra