FluoroFinder

	CD357	This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

		Human peripheral blood lymphocytes were activated for three days with PHA, and then stained with CD3 FITC and biotinylated CD357 (clone 108-17, top) or biotinylated mouse IgG2a, κ isotype control (bottom), followed by Sav-PE.