CD117 / APC / 104D2

Product Details
Supplier BioLegend
Catalog #: 983302 (View supplier product page)
Size 500UL
Price $363.00
Antigen CD117
Clone 104D2
Host Mouse
Isotype IgG1 κ
Conjugate APC
Target Species Human
Applications FC
Description APC anti-human CD117 (c-kit)
About CD117 and APC
CD117 This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
APC Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Images
  CD117 APC BioLegend antibody anti target:Human host:Mouse isotype:IgG1 κ clone:104D2

Typical results from human erythroleukemia cell line TF-1 stained either with 104D2 APC used at 5 µL/test (solid line) or with an isotype control (dotted line).
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

APC Excitation and Emission Spectra