IL-8 Monoclonal / APC / REA731

Citations: (3)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-112-016 (View supplier product page)
Size 30 tests in 60 µL
Price $145.00
Antigen IL-8
Clone REA731
Host Human
Isotype IgG1
Conjugate APC
Target Species Human
Applications FC
Description Clone REA731 recognizes the human IL-8 chemokine, a heterodimer also known as interleukin 8 or CXCL8 (chemokine (C-X-C motif) ligand 8. IL-8 is secreted by macrophages, epithelial cells, airway smooth muscle cells, and endothelial cells. IL-8 plays a role in neutrophil activation, is a potent promoter of angiogenesis, and attracts neutrophils, basophils, and T cells. Clone REA731 recognizes both the 72 and 77 amino acid isoforms of human IL-8. | Additional information: Clone REA731 displays negligible binding to Fc receptors.
About IL-8 and APC
IL-8 The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]
APC Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Citations
PMID 2212672
PMID 2491503
PMID 2663993
Additional
Sources
Reviews & Ratings
Submit a Review

APC Excitation and Emission Spectra