MSR1 / PE-Cy7 / 7C9C20
MSR1 / PE-Cy7 / 7C9C20
Citations:
(1)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 371907 (View supplier product page) | |
| Size | 25T | |
| Price | $165.00 | |
| Antigen | MSR1 | |
| Clone | 7C9C20 | |
| Host | Mouse | |
| Isotype | IgG2a κ | |
| Conjugate | PE-Cy7 | |
| Target Species | Human | |
| Applications | FC | |
| Description | PE/Cyanine7 anti-human CD204 |
About MSR1 and PE-Cy7
| MSR1 | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| PE-Cy7 | PE-Cyanine®7 (PE-Cy7, RPE-Cy7) is a far red-emitting tandem fluorophore that combines phycoerythrin (PE) and Cy7. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Cy7, which emits light that can be captured with a 780/60 nm bandpass filter. PE-CY7 has an excitation peak at 565 nm and an emission peak at 778 nm, and is a suitable alternative to PE-Vio®770 (Miltenyi) and cFluor BYG781 (Cytek). |
Images
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Human peripheral blood monocytes were stimulated with GM-CSF (6 days), then stained with CD204 (clone 7C9C20) PE/Cy7 (filled histogram) or mouse IgG2a, κ isotype control PE/Cy7 (open histogram). |
Citations
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Reviews & Ratings
PE-Cy7 Excitation and Emission Spectra
$165.00
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