CD95 / PE / SA367H8

Citations: (19)
Product Details
Supplier BioLegend
Catalog #: 152607 (View supplier product page)
Size 25 μg
Price $117.00
Antigen CD95
Clone SA367H8
Host Mouse
Isotype IgG1 κ
Conjugate PE
Target Species Mouse
Applications FC
Description PE anti-mouse CD95 (Fas)
About CD95 and PE
CD95 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
PE Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Images
  CD95 PE BioLegend antibody anti target:Mouse host:Mouse isotype:IgG1 κ clone:SA367H8

C57BL/6 thymocytes were stained with CD95 (clone SA367H8) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
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PE Excitation and Emission Spectra