LGR5 / Brilliant Ultraviolet 395 / 4D11F8 (also known as 4D11)

Product Details
Supplier BD Biosciences
Catalog #: 743971 (View supplier product page)
Size 50 μg
Price $538.00
Antigen LGR5
Clone 4D11F8 (also known as 4D11)
Host Rat
Isotype IgG2b λ
Conjugate Brilliant Ultraviolet 395
Target Species Human
Applications FC
Description Hu Lgr5 BUV395 4D11F8 50ug
About LGR5 and Brilliant Ultraviolet 395
LGR5 The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Brilliant Ultraviolet 395 Brilliant™ UltraViolet 395 (BUV395) is a UV-emitting base polymer dye that can be excited by the 355 nm UV laser and collected using a 379/28 bandpass filter. BUV395 has an excitation peak at 348 nm and an emission peak at 395. BUV395's fairly unique excitation and emission spectrum causes relatively little spillover into other common detectors and conflicts with very few other commonly used fluorophores. An alternative to BUV395 for flow cytometry is StarBright UltraViolet 400. This dye is part of the Brilliant™ UltraViolet dye family, developed and sold by BD Biosciences. These dyes were optimized for use with multicolor flow cytometry. BUV395 forms the backbone of the family, as all other members are tandems that use it as the acceptor, thus making them excitable by the same 355 nm UV laser.
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Brilliant Ultraviolet 395 Excitation and Emission Spectra