CD321 / Brilliant Ultraviolet 395 / M.Ab.F11

Product Details
Supplier BD Biosciences
Catalog #: 744069 (View supplier product page)
Size 50 μg
Price $538.00
Antigen CD321
Clone M.Ab.F11
Host Mouse
Isotype IgG1 κ
Conjugate Brilliant Ultraviolet 395
Target Species Human
Applications FC
Description Hu CD321 (JAM-1) BUV395 M.AB.F11 50ug
About CD321 and Brilliant Ultraviolet 395
CD321 Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
Brilliant Ultraviolet 395 Brilliant™ UltraViolet 395 (BUV395) is a UV-emitting base polymer dye that can be excited by the 355 nm UV laser and collected using a 379/28 bandpass filter. BUV395 has an excitation peak at 348 nm and an emission peak at 395. BUV395's fairly unique excitation and emission spectrum causes relatively little spillover into other common detectors and conflicts with very few other commonly used fluorophores. An alternative to BUV395 for flow cytometry is StarBright UltraViolet 400. This dye is part of the Brilliant™ UltraViolet dye family, developed and sold by BD Biosciences. These dyes were optimized for use with multicolor flow cytometry. BUV395 forms the backbone of the family, as all other members are tandems that use it as the acceptor, thus making them excitable by the same 355 nm UV laser.
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Brilliant Ultraviolet 395 Excitation and Emission Spectra