FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-110-799 (View supplier product page)
	Size	30 µg in 200 µL
	Price	$175.00
	Antigen	CD45
	Clone	REA737
	Host	Human
	Isotype	IgG1
	Conjugate	PE-Vio770
	Target Species	Mouse
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), 3D-IF, IF, IHC
	Description	Clone REA737 recognizes the mouse CD45 antigen, also known as Ly-5 or leukocyte common antigen (LCA), which belongs to the protein tyrosine phosphatase (PTP) family. CD45 is a glycoprotein which is involved in T cell receptor and B cell receptor signal transduction. It is expressed at high levels on all cells of hematopoietic origin except for erythrocytes. Clone REA737 reacts with all CD45 isoforms. CD45 can be used to discriminate leukocytes from non-hematopoietic cells. \| Additional information: Clone REA737 displays negligible binding to Fc receptors.

	CD45	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
	PE-Vio770	PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.

$175.00
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CD45 Monoclonal / PE-Vio770 / REA737