LIME Monoclonal / Unconjugated / LIME-06

Product Details
Supplier EXBIO
Catalog #: 11-400-C100 (View supplier product page)
Size 100 μg
Price $180.00
Antigen LIME
Clone LIME-06
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Target Species Human
Applications IP
Description LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
About LIME and Purified
LIME This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]
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Purified Excitation and Emission Spectra