CD45RA Monoclonal / Biotin / MEM-56

Product Details
Supplier EXBIO
Catalog #: 1B-223-C025 (View supplier product page)
Size 25 μg
Price $90.00
Antigen CD45RA
Clone MEM-56
Host Mouse
Isotype IgG2b
Conjugate Biotin
Target Species Human
Applications FC, IP, WB, IHC-P, CyTOF
Description CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed e.g. on naïve T cells and normal plasma cells.
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Biotin Excitation and Emission Spectra