BRCC3 / DyLight 550 / 3B1

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-30429R (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen BRCC3
Clone 3B1
Host Mouse
Isotype IgG1 κ
Conjugate DyLight 550
Target Species Human, Mouse
Applications WB, ELISA
About BRCC3 and DyLight 550
BRCC3 This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
DyLight 550 DyLight™ 550 has an excitation peak at 562 nm and an emission peak at 576 nm and is spectrally similar to Alexa Fluor™ 546, Alexa Fluor™ 555, Cy3 and TRITC. DyLight™ 550 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 550 Excitation and Emission Spectra