BNP / Alexa Fluor 405 / 5-E2/50E1

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-62133AF405 (View supplier product page)
Size 100 μl
Price $399.00
Antigen BNP
Clone 5-E2/50E1
Host Mouse
Isotype IgG1
Conjugate Alexa Fluor 405
Target Species Human
Applications WB, ELISA
Description NB100-62133 detects an epitope located at the C-terminal (amino acids 26-32) of the human brain natriuretic peptide (BNP). This clone also known as 50E1.
About BNP and Alexa Fluor 405
BNP This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra