Presenilin-1 / DyLight 755 / 24-4B5

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-78993IR (View supplier product page)
Size 100 μl
Price $379.00
Antigen Presenilin-1
Clone 24-4B5
Host Rat
Isotype IgG1
Conjugate DyLight 755
Target Species Human, Mouse, Rat
Applications WB, IHC
Description Rat Presenilin-1 antibody [DyLight 755] detects Human, Mouse, Rat
About Presenilin-1 and DyLight 755
Presenilin-1 Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
DyLight 755 DyLight™ 755 has an excitation peak of 754 nm and an emission peak of 776 nm and is spectrally similar to Alexa Fluor™ 750. DyLight™ 755 is most commonly used in fluorescence micrscopy.
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DyLight 755 Excitation and Emission Spectra