Presenilin-1 Monoclonal / Alexa Fluor 405 / 24-4B5

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-78993AF405 (View supplier product page)
Size 100 μl
Price $379.00
Antigen Presenilin-1
Clone 24-4B5
Host Rat
Isotype IgG1
Conjugate Alexa Fluor 405
Target Species Human, Mouse, Rat
Applications WB, IHC
Description Rat Presenilin-1 antibody [Alexa Fluor 405] detects Human, Mouse, Rat
About Presenilin-1 and Alexa Fluor 405
Presenilin-1 Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Alexa Fluor 405 Excitation and Emission Spectra