NCF4 / Unconjugated /
NCF4 / Unconjugated /
Product Details
| Supplier | Thermo Fisher Scientific | |
|---|---|---|
| Catalog #: | PA5-14593 (View supplier product page) | |
| Size | 400 μl | |
| Price | $330.00 | |
| Antigen | NCF4 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | WB, FC, IHC-P | |
| Description | NCF4 Polyclonal Antibody |
About NCF4 and Purified
| NCF4 | The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
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Images
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Flow cytometry analysis of K562 cells using a NCF4 polyclonal antibody (Product # PA5-14593) (bottom) compared to a negative control cell (top) at a dilution of 1:10-50, followed by a FITC-conjugated goat anti-rabbit antibody |
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra
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