CD25 Monoclonal / Unconjugated / OX-39
CD25 Monoclonal / Unconjugated / OX-39
Citations:
(1)
Product Details
| Supplier | Thermo Fisher Scientific | |
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| Catalog #: | MA1-70019 (View supplier product page) | |
| Size | 250 µg | |
| Price | $365.00 | |
| Antigen | CD25 | |
| Clone | OX-39 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | Unconjugated | |
| Target Species | Rat | |
| Applications | Functional, IHC-P, IP, FC, IHC | |
| Description | CD25 Monoclonal Antibody (OX-39) |
About CD25 and Purified
| CD25 | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020] |
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Images
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Flow cytometric analysis of Con-A Activated thymocytes stained using a CD25/IL-2R alpha chain monoclonal antibody (Product # MA1-70019) at a 1.0 µg/10^6 cells dilution. The isotype control was a mouse IgG1, kappa |
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra
$365.00
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